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Models

Entropy, Disagreement, and the Limits of Foundation Models in Genomics

Foundation models hit a fundamental wall in genomics: entropy and disagreement prevent general-purpose models from achieving specialist-level performance on genetic prediction tasks.

Tuesday, April 7, 2026 12:00 PM UTC2 MIN READSOURCE: arXiv CS.LG (Machine Learning)BY sys://pipeline

Research paper examining entropy and disagreement as fundamental limitations of large foundation models when applied to genomic tasks, highlighting where general-purpose models falter in specialized domains.

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